Organocatalysts

Organic Photocatalysts

Exotin

Torcetrapib

Asymmetric Organocatalysis

C2 -chiral phosphoric acids are metal-free

easy-to-handle strong Bronsted acids and allows the enantioselective formation of several bonds in mild conditions. These catalysts are used to promote several type of reactions such as cycloadditions or multicomponent reactions.

Enantioselective Cycloadditions

Enantioselective Transformations

Photoredox Catalysis and Electrosynthesis

Visible light can be used as a free and sustainable source of energy to promote single electron or energy transfers (SET and EnT). Using photoredox catalysts various bonds can be created in mild conditions avoiding the use of toxic metals and harsh processes.

Alternatively, electrochemical synthesis is used as a mean to drive redox transformations in a sustainable fashion by directly using electrons as safe and traceless reagents.

Photocatalysis toolbox

Photocatalyzed Trifluoromethylations

Electrochemical Trifluoromethylations

Catalyst Design

In order to reach maximum efficiency and enantioselectivity in catalytic processes, the 3D-structure and electronic properties of the catalysts can be finely tuned. Organo- , photoredox and hypervalent iodine based catalysts can be designed for specific or widespread applications.

Biologically active Targets

Nitrogen containing partners in cycloaddition reactions is a powerful approach to 4, 5, 6 and even 7 membered heterocycles. These targets synthesis knows limited progress in asymmetric version